Histamine H3 Receptor Agonists Decrease Hypothalamic Histamine Levels and Increase Stereotypical Biting in Mice Challenged with Methamphetamine
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چکیده
منابع مشابه
Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes in histamine H3-receptor knockout mice.
Histamine H(3) receptors inhibit the release of not only histamine itself, but also other neurotransmitters including dopamine. Previous papers have reported that histaminergic neurons inhibit psychostimulant-induced behavioral changes. To examine whether deficiency in histamine H(3) receptors influences psychostimulant-induced behavioral sensitization and reward, we examined locomotor activity...
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This article has not been copyedited and formatted. The final version may differ from this version. Abbreviations Imetit, 2-(1H-imidazol-5-yl)ethyl imidothiocarbamate, iodoproxyfan, 3-(1H-imidazol-4-yl)propyl-(4-iodophenyl)-methyl ether, proxyfan, 4-[3-(benzyloxy)propyl]-1H-imidazole, NαMH, N-α-methylhistamine dihydrochloride, pERK, phosphorylated extracellular signal-regulated kinase, RαMH, (R...
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BACKGROUND Histamine is a biogenic amine that has been shown to contribute to several pathological conditions, such as allergic conditions, experimental encephalomyelitis, and malaria. In humans, as well as in murine models of malaria, increased plasma levels of histamine are associated with severity of infection. We reported recently that histamine plays a critical role in the pathogenesis of ...
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The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R antagonists as antiallergy drugs and to address the question of whether H(1)R ligands bind to hH(4)R. In an acute murine asthma model, the H(1)R antago...
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BF2.649, a high affinity and selective non-imidazole histamine H(3)-receptor antagonist/inverse agonist, was found to easily enter the brain after oral administration to mice: it displayed a ratio of brain/plasma levels of about 25 when considering either C(max) or AUC values. At low oral doses (2.5-20mg/kg), it elicited in mice a dose-dependent wakening effect accompanied with a shift towards ...
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ژورنال
عنوان ژورنال: Neurochemical Research
سال: 2011
ISSN: 0364-3190,1573-6903
DOI: 10.1007/s11064-011-0500-8